HSPH1 Human-Heat Shock Protein

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HSPH1 Human

Qty


Total
$65
Catalog #
HYPS-112
Size
Description
Recombinant HSPH1 produced in E.Coli is a single, non-glycosylated polypeptide chain containing 894 amino acids and having a molecular mass of 100.9kDa. HSP105 Alpha is fused with a 36 a.a. His tag and purified by conventional chromatography techniques.
Additional Information
IntroductionHSPH1 analysis is used as an indicator and as a diagnostic aid in problematic lesions. HSPH1 chaperones the responses to endoplasmic reticulum (ER) stress during its interactions with GRP78 and GSK3, and without HSP105 cell death following ER stress proceeds by a non-caspase-3-dependent process. HSPH1 is highly expressed in a variety of human tumors.HSPH1 is a mammalian member of the HSP105/110 family, a diverged subgroup of the HSP70 family. HSP105 has 2 isoforms, alpha and beta. Hsp105a associates with Hsp70/Hsc70 as complexes in vivo and regulates the chaperone activity of Hsp70/Hsc70 negatively in vitro and in vivo.
SynonymsHSPH1, Heat Shock protein 105kDa, 110kDa protein 1, Heat shock 110 kDa protein, HSP110, HSP105A, Antigen NY-CO-25, HSP105, HSP105A, HSP105B, KIAA0201, NY-CO-25, DKFZp686M05240.
SourceEscherichia Coli.
Physical AppearanceSterile filtered colorless solution.
FormulationThe HSP105 protein solution contains 20mM Tris-HCl, pH-8 and 50mM NaCl.
StabilityStore at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Avoid multiple freeze-thaw cycles.
Amino Acid SequenceMRGSHHHHHH
GMASMTGGQQ
MGRDLYDDDD
KDRWGSMSVV
GLDVGSQSCY
IAVARAGGIE
TIANEFSDRC
TPSVISFGSK
NRTIGVAAKN
QQITHANNTV
SNFKRFHGRA
FNDPFIQKEK
ENLSYDLVPL
KNGGVGIKVM
YMGEEHLFSV
EQITAMLLTK
LKETAENSLK
KPVTDCVISV
PSFFTDAERR
SVLDAAQIVG
LNCLRLMNDM
TAVALNYGIY
KQDLPSLDEK
PR
PurityGreater than 90.0% as determined by SDS-PAGE.
UsageNeoScientific's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drµgs, agricultural or pesticidal products, food additives or household chemicals.
Background

N/A

Protocol

N/A

MSDS
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