IL 13 Rhesus Macaque-Interleukin

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IL 13 Rhesus Macaque

Qty


Total
$65
Catalog #
CYPS-182
Size
Description
IL 13 Rhesus Macaque Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 114 amino acids and having a molecular mass of 12.6kDa.The IL 13 Rhesus Macaque is purified by proprietary chromatographic techniques.
Additional Information
IntroductionIL13 is an immunoregulatory cytokine produced primarily by activated Th2 cells. IL-13 is involved in several stages of B-cell maturation and differentiation. It up-regulates CD23 and MHC class II expression, and promotes IgE isotype switching of B cells. This cytokine down-regulates macrophage activity, thereby inhibits the production of pro-inflammatory cytokines and chemokines. This cytokine is found to be critical to the pathogenesis of allergen-induced asthma but operates throµgh mechanisms independent of IgE and eosinophils. This gene, IL3, IL5, IL4, and CSF2 form a cytokine gene cluster on chromosome 5q, with this gene particularly close to IL4.
SynonymsNC30, ALRH, BHR1, P600, IL-13, MGC116786, MGC116788, MGC116789.
SourceEscherichia Coli.
Physical AppearanceSterile Filtered White lyophilized (freeze-dried) powder.
FormulationLyophilized from a 0.2?m filtered concentrated solution in PBS, pH 7.4 containing 5% trehalose.
SolubilityIt is recommended to reconstitute the lyophilized IL-13 in sterile 18M-cm H2O not less than 100
StabilityLyophilized IL-13 althoµgh stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution IL-13 should be stored at 4°C between 2-7 days and for future use below -18°C.Please prevent freeze-thaw cycles.
Amino Acid SequenceSPSPVPRSTA
LKELIEELVN
ITQNQKAPLC
NGSMVWSINL
TAGVYCAALE
SLINVSGCSA
IEKTQRMLNG
FCPHKVSAGQ
FSSLRVRDTK
IEVAQFVKDL
LVHLKKLFRE
GRFN
PurityGreater than 97.0% as determined by SDS-PAGE and HPLC analyses.
Biological ActivityThe ED50 as determined by the dose-dependent proliferation of TF-1 cells was < 1.0 ng/ml, corresponding to a specific activity of > 1
UsageNeoScientific's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drµgs, agricultural or pesticidal products, food additives or household chemicals.
Background

N/A

Protocol

N/A

MSDS
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