KLK3 Human-Kallikrein

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KLK3 Human

Qty


Total
$65
Catalog #
ENPS-627
Size
Description
KLK3 Human Recombinant produced in E.coli is a single, non-glycosylated polypeptide chain containing 262 amino acids (25-261) and having a molecular mass of 28.8kDa.The KLK3 is fused to a 25 amino acid His-Tag at N-terminus and purified by proprietary chromatographic techniques.
Additional Information
IntroductionKallikrein-3 (KLK3) belongs to the kallikrein-related peptidase family. Kallikreins are a subgroup of serine proteases having various physiological functions. Numerous kallikreins are involved in carcinogenesis and some may be NeoBiolabtive cancer and other disease biomarkers. Kallikrein-3 is 1 of the 15 kallikrein subfamily members located in a cluster on chromosome 19 and is a protease present in seminal plasma. KLK3 hydrolyzes semenogelin-1 consequently leading to the liquefaction of the seminal coagulum. KLK3 is assumed to act normally in the liquefaction of seminal coagulum, probably by hydrolysis of the high molecular mass seminal vesicle protein. Serum level of the KLK3 protein, called PSA in the clinical setting, is beneficial in the diagnosis and monitoring of prostatic carcinoma.
SynonymsProstate-specific antigen, PSA, Gamma-seminoprotein, Seminin, Kallikrein-3, P-30 antigen, Semenogelase, KLK3, APS, hK3, KLK2A1.
SourceEscherichia Coli.
Physical AppearanceSterile Filtered clear solution.
FormulationKLK3 protein solution (1mg/ml) is supplied in 20mM Tris-HCl buffer (pH8.0) and 0.4M Urea.
StabilityStore at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Amino Acid SequenceMGSSHHHHHH
SSGLVPRGSH
MGSHMIVGGW
ECEKHSQPWQ
VLVASRGRAV
CGGVLVHPQW
VLTAAHCIRN
KSVILLGRHS
LFHPEDTGQV
FQVSHSFPHP
LYDMSLLKNR
FLRPGDDSSH
DLMLLRLSEP
AELTDAVKVM
DLPTQEPALG
TTCYASGWGS
IEPEEFLTPK
KLQCVDLHVI
SNDVCAQVHP
QKVTKFMLCA
GRWTGGKSTC
SGDSGGPLVC
NGVLQGITSW
GS
PurityGreater than 90.0% as determined by SDS-PAGE.
UsageNeoScientific's products are furnished forLABORATORY RESEARCHUSEONLY. The product may not be used as drµgs, agricultural or pesticidal products, food additives or household chemicals.
Background

N/A

Protocol

N/A

MSDS
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