Leptin Mouse-Leptin

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Leptin Mouse

Qty


Total
$65
Catalog #
CYPS-358
Size
Description
Leptin Mouse Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 147 amino acids and having a molecular mass of 16.2 kDa.The Leptin is purified by proprietary chromatographic techniques.
Additional Information
IntroductionA 16-kDa peptide hormone secreted from white adipocytes and implicated in the regulation of food intake and energy balance. Leptin provides the key afferent signal from fat cells in the feedback system that controls body fat stores.
SynonymsOB Protein, Obesity Protein, OBS, Obesity factor.
SourceEscherichia Coli.
Physical AppearanceSterile Filtered White lyophilized (freeze-dried) powder.
FormulationThe mouse Leptin was lyophilized from a concentrated (1mg/ml) solution containing 0.1% TFA.
SolubilityIt is recommended to reconstitute the lyophilized Leptin in sterile 18MΩ-cm H2O not less than 100µg/ml, which can then be further diluted to other aqueous solutions.
StabilityLyophilized Leptin althoµgh stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution Leptin should be stored at 4°C between 2-7 days and for future use below -18°C.For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please prevent freeze-thaw cycles.
Amino Acid SequenceMVPIQKVQDD
TKTLIKTIVT
RINDISHTQS
VSAKQRVTGL
DFIPGLHPIL
SLSKMDQTLA
VYQQVLTSLP
SQNVLQIAND
LENLRDLLHL
LAFSKSCSLP
QTSGLQKPES
LDGVLEASLY
STEVVALSRL
QGSLQDILQQ
LDVSPEC.
PurityGreater than 95.0% as determined by:(a) Analysis by SEC-HPLC.(b) Analysis by SDS-PAGE.
Biological ActivityBiological activity of Mouse Leptin is performed in two different mouse obesity models, ob/ob and NZO. Both strains of mice were treated via intraperitoneal injection once daily at a dose of 5µg Leptin/gram body weight for a period of 14 days. Significant effects on body weight , food consumption, and plasma glucose levels were observed to saline-treated controls.
UsageNeoScientific's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drµgs, agricultural or pesticidal products, food additives or household chemicals.
ReferencesTitle:Severe pulmonary metastasis in obese and diabetic mice.Publication: Article first published online: 22 SEP 2006 DOI:10.1002/ijc.22248 Copyright
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