LGALS3 Human-Galectin

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LGALS3 Human

Qty


Total
$65
Catalog #
CYPS-613
Size
Description
LGALS3 Human Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 250 amino acids and having a molecular mass of 26 kDa.The LGALS3 is purified by proprietary chromatographic techniques.
Additional Information
IntroductionGalectin-3 mediates with the alpha-3, beta-1 integrin the stimulation by cspg4 of endothelial cells migration. Galectin-3 plays an necessary part during the acquisition of vasculogenic mimicry and angiogenic properties associated with melanoma progression. LGALS3 overexpression is highly expressed in early stages of papillary carcinoma, and its expression intensity declines during tumor progression. Serum levels of LGALS3 are high in patients with thyroid malignancy but there is considerable overlap in serum LGALS3 concentrations between those with benign and malignant nodular thyroid disease. LGLAS3 takes part as an immune regulator to inhibit T-cell immune responses and promote tumor growth, as a result providing a new mechanism for tumor immune tolerance.
SynonymsGalectin-3, GAL3, MAC2, CBP35, GALB, GALIG, LGALS2, LGALS3, Galactose-specific lectin 3, Mac-2 antigen, IgE-binding protein, 35 kDa lectin, Carbohydrate-binding protein 35, CBP 35, Laminin-binding protein, Lectin L-29, L-31, Galactoside-binding protein, G
SourceEscherichia Coli.
Physical AppearanceSterile Filtered White lyophilized (freeze-dried) powder.
FormulationThe Galectin-3 protein was lyophilized from a concentrated (1mg/ml) containing 10mM Na2PO4 buffer, pH-7.5 and 50mM NaCl.
SolubilityIt is recommended to reconstitute the lyophilized LGALS3 in sterile 18MΩ-cm H2O not less than 100µg/ml, which can then be further diluted to other aqueous solutions.
StabilityLyophilized Galectin-3 Recombinant althoµgh stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution Galectin-3 should be stored at 4°C between 2-7 days and for future use below -18°C.For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please prevent freeze-thaw cycles.
Amino Acid SequenceMADNFSLHDA
LSGSGNPNPQ
GWPGAWGNQP
AGAGGYPGAS
YPGAYPGQAP
PGAYPGQAPP
GAYHGAPGAY
PGAPAPGVYP
GPPSGPGAYP
SSGQPSAPGA
YPATGPYGAP
AGPLIVPYNL
PLPGGVVPRM
LITILGTVKP
NANRIALDFQ
RGNDVAFHFN
PRFNENNRRV
IVCNTKLDNN
WGREERQSVF
PFESGKPFKI
QVLVEPDHFK
VAVNDAHLLQ
YNHRVKKLNE
IS
PurityGreater than 97.0% as determined by SDS-PAGE.
Biological ActivityThe activity as determined by its ability to induce chemotaxis of human PBMCs is detectable starting at 1
UsageNeoScientific's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drµgs, agricultural or pesticidal products, food additives or household chemicals.
Background

N/A

Protocol

N/A

MSDS
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