MAGEA3 Human-Melanoma Antigen Family A

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MAGEA3 Human

Qty


Total
$65
Catalog #
PRPS-509
Size
Description
MAGEA3 produced in E.Coli is a single, non-glycosylated polypeptide chain containing 337 amino acids (1-314 a.a.) and having a molecular mass of 37.1kDa.MAGEA3 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
Additional Information
IntroductionMAGE belongs to the MAGE gene family, that comprises 12 known genes, of which 6 are expressed in tumors. The Melanoma-associated antigen 3 genes were originally isolated from different kinds of tumors, and based on their virtually limited tumor-specific expression in adult tissues, they were used as targets for cancer immunotherapy. MAGEA3 is a tumor-specific antigen extensively expressed in solid and hematologic malignancies, but not in normal tissues, with the exclusion of testis and placenta. Consequently, MAGEA3 is an outstanding candidate tumor antigen.
SynonymsCT1.3, MAGE3, HYPD, Melanoma Antigen family A, 3, MAGE-3 antigen, MAGEA6, Antigen MZ2-D, Melanoma-Associated antigen 3.
SourceEscherichia Coli.
Physical AppearanceSterile Filtered clear solution.
FormulationThe MAGEA3 protein solution (1mg/1ml) is formulated in 20mM Tris-HCl buffer (pH 8.0) 1mM DTT, 100mM NaCl and 10% glycerol.
StabilityStore at 4°C if entire vial will be used within 2-4 weeks.Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Amino Acid SequenceMGSSHHHHHH
SSGLVPRGSH
MGSMPLEQRS
QHCKPEEGLE
ARGEALGLVG
AQAPATEEQE
AASSSSTLVE
VTLGEVPAAE
SPDPPQSPQG
ASSLPTTMNY
PLWSQSYEDS
SNQEEEGPST
FPDLESEFQA
ALSRKVAELV
HFLLLKYRAR
EPVTKAEMLG
SVVGNWQYFF
PVIFSKASSS
LQLVFGIELM
EVDPIGHLYI
FATCLGLSYD
GLLGDNQIMP
KAGLLIIVLA
II
PurityGreater than 90% as determined by SDS-PAGE.
UsageNeoScientifics products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drµgs, agricultural or pesticidal products, food additives or household chemicals.
Background

N/A

Protocol

N/A

MSDS
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