NME2 Human-Non-Metastatic Cells

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NME2 Human

Qty


Total
$65
Catalog #
PKPS-370
Size
Description
NME2 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 152 amino acids (1-152 a.a.) and having a molecular mass of 17.2kDa. The NME2 is purified by conventional chromatography.
Additional Information
IntroductionNME2 takes an important part in the synthesis of nucleoside triphosphates other than ATP. NME2 negatively controls Rho activity by interacting with AKAP13/LBC. NME2 acts as a transcriptional activator of the MYC gene. NME2 binds DNA non-specifically. NME2 is a heterodimeric enzyme functioning as a nucleoside diphosphate kinase. NME1 and NME2 contain 152 amino acids, A and B polypeptide chains of the NM23 enzyme, respectively. NME2 is identical to the beta subunit of human erythrocyte NDP kinase. NDP kinases participate in the synthesis of nucleoside triphosphates, and NM23 is involved in the regulation of signal transduction by complexing with G proteins, causing activation/inactivation of developmental pathways.
SynonymsNucleoside diphosphate kinase B, NDPK-B, NDPKB, NM23-H2, NM23B, EC 2.7.4.6, NDP kinase B, C-myc purine-binding transcription factor PUF, NDK B, NME2, puf, MGC111212.
SourceEscherichia Coli.
Physical AppearanceSterile Filtered colorless solution.
FormulationThe NME2 protein solution contains 20mM Tris-HCl pH-8, 1mM DTT, and 10% glycerol.
StabilityNME2 althoµgh stable 4°C for 4 weeks, should be stored desiccated below -18°C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please prevent freeze-thaw cycles.
Amino Acid SequenceMANLERTFIA
IKPDGVQRGL
VGEIIKRFEQ
KGFRLVAMKF
LRASEEHLKQ
HYIDLKDRPF
FPGLVKYMNS
GPVVAMVWEG
LNVVKTGRVM
LGETNPADSK
PGTIRGDFCI
QVGRNIIHGS
DSVKSAEKEI
SLWFKPEELV
DYKSCAHDWV
YE.
PurityGreater than 95.0% as determined by SDS-PAGE.
UsageNeoScientific's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drµgs, agricultural or pesticidal products, food additives or household chemicals.
Background

N/A

Protocol

N/A

MSDS
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