PF 4 Human-Platelet Factor-4 (CXCL4)

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PF 4 Human

Qty


Total
$65
Catalog #
CHPS-241
Size
Description
Human PF-4 a 7.8 kDa protein consisting of 70 amino acid residues.
Additional Information
IntroductionPlatelet factor-4 is a 70-amino acid protein that is released from the alpha-granules of activated platelets and binds with high affinity to heparin. Its major physiologic role appears to be neutralization of heparin-like molecules on the endothelial surface of blood vessels, thereby inhibiting local antithrombin III activity and promoting coagulation. As a strong chemoattractant for neutrophils and fibroblasts, PF4 probably has a role in inflammation and wound repair. Oncostatin-A is a member of the CXC chemokine family. Human PF4 is used for the proof of heparin-induced thrombocytopenia. Furthermore it is used as an inhibitor in the angiogenesis during tumor therapy.
SynonymsCXCL4, PF-4, PF4, Iroplact, Oncostatin-A, SCYB4, MGC138298.
SourceHuman Platelets.
Physical AppearanceSterile Filtered white lyophilized powder.
FormulationThe CXCL4 protein was lyophilized in PBS buffer pH-7.4.
SolubilityIt is recommended to reconstitute the lyophilized CXCL4 in sterile 18MΩ-cm H2O not less than 100µg/ml, which can then be further diluted to other aqueous solutions.
StabilityHuman CXCL4 althoµgh stable at 25°C 1 week, should be stored desiccated below -18°C. Please prevent freeze-thaw cycles.
Amino Acid SequenceThe
sequence
of
the
first
four
N-terminal
amino
acids
was
determined
and
was
found
to
be
Glu-Ala-Glu-Glu.
PurityGreater than 95.0% as determined by(a) Analysis by RP-HPLC.(b) Analysis by SDS-PAGE.
UsageNeoScientific's products are furnished for LABORATORY RESEARCH USE ONLY.They may not be used as drµgs,agricultural or pesticidal products, food additives or household chemicals.
Background

N/A

Protocol

N/A

MSDS
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