PHB Human-Other

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PHB Human

Qty


Total
$65
Catalog #
PRPS-1388
Size
Description
PHB Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 292 amino acids (1-272a.a) and having a molecular mass of 31.9kDa. PHB is fused to a 20 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
Additional Information
IntroductionProhibitin (PHB) is an evolutionarily conserved gene that is ubiquitously expressed and which Mutations have been linked to sporadic breast cancer. PHB is thoµght to be a negative regulator of cell proliferation and may be a tumor suppressor. Prohibitin is expressed as two transcripts with changeable lengths of 3' untranslated region. The longer transcript is present at higher levels in proliferating tissues and cells, proposing that this longer 3' untranslated region functions as a trans-acting regulatory RNA.
SynonymsPHB1, Prohibitin.
SourceE.coli.
Physical AppearanceSterile Filtered colorless solution.
FormulationPHB protein solution (1mg/ml) containing 20mM Tris-HCl buffer (pH8.0), 10% glycerol and 0.1M NaCl.
StabilityStore at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Amino Acid SequenceMGSSHHHHHH
SSGLVPRGSH
MAAKVFESIG
KFGLALAVAG
GVVNSALYNV
DAGHRAVIFD
RFRGVQDIVV
GEGTHFLIPW
VQKPIIFDCR
SRPRNVPVIT
GSKDLQNVNI
TLRILFRPVA
SQLPRIFTSI
GEDYDERVLP
SITTEILKSV
VARFDAGELI
TQRELVSRQV
SDDLTERAAT
FGLILDDVSL
THLTFGKEFT
EAVEAKQVAQ
QEAERARFVV
EKAEQQKKAA
II
PurityGreater than 85% as determined by SDS-PAGE.
UsageNeoScientific's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drµgs, agricultural or pesticidal products, food additives or household chemicals.
Background

N/A

Protocol

N/A

MSDS
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