PKA-RII alpha-Protein Kinase-A

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PKA-RII alpha

Qty


Total
$65
Catalog #
PKPS-211
Size
Description
The recombinant PKA regulatory subunit II-a is a dimeric 90 kDa protein. Protein Kinase A is purified by proprietary chromatographic techniques.
Additional Information
IntroductioncAMP-dependent PKA is a ubiquitous serine/theonine protein kinase present in a variety of tissues (e.g. brain, skeletal muscle, heart). The intracellular cAMP level regulates cellular responses by altering the interaction between the catatytic C and regulatory R subunits of PKA. The inactive tetrameric PKA holoenzyme R2C2 is activated when cAMP binds to R2, which dissociates the tetramer to R2 cAMP 4 and two active catalytic subunits. Free Catalytic subunits of PKA can phosphorylate a wide variety of intracellular target proteins. In response to hormone- induced high cAMP levels, PKA phosphorylates glycogen synthetase (inhibition of the enzyme activity) and phosphorylase kinase to block glycogen synthesis. Different isoforms of catalytic and regulatory subunits sµggest specific functions.
SynonymscAMP-Dependent Protein Kinase A regulatory subunit-II A, PKA-RII alpha.
SourceEscherichia Coli.
Physical AppearanceSterile Filtered clear solution.
FormulationPKA regulatory subunit-II alpha is supplied at a concentration of 0.37mg/ml in 20mM MES, 150mM NaCl, 2mM EDTA, 2mM EGTA, 1mM BME and 50% glycerol.
StabilityPKA should be stored at 4°C if entire vial will be used within 1 week. For long term storage below -20°C.Avoid multiple freeze-thaw cycles.
Amino Acid SequenceMSHIQIPPGL
TELLQGYTVE
VLRQQPPDLV
EFAVEYFTRL
REARAPASVL
PAATPRQSLG
HPPPEPGPDR
VADAKGDSES
EEDEDLEVPV
PSRFNRRVSV
CAETYNPDEE
EEDTDPRVIH
PKTDEQRCRL
QEACKDILLF
KNLDQEQLSQ
VLDAMFERIV
KADEHVIDQG
DDGDNFYVIE
RGTYDILVTK
DNQTRSVGQY
DNRGSFGELA
LMYNTPRAAT
IVATSEGSLW
GL
PurityGreater than 95% as determined by SDS-PAGE.
UsageNeoScientific's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drµgs, agricultural or pesticidal products, food additives or household chemicals.
Background

N/A

Protocol

N/A

MSDS
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