POMC Human-Other

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POMC Human

Qty


Total
$65
Catalog #
PRPS-243
Size
Description
POMC produced in E.Coli is a single, non-glycosylated polypeptide chain containing 262 amino acids (27-267 a.a) and having a molecular mass of 28.9kDa (molecular weight on SDS-PAGE will appear higher).POMC is fused to a 21 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
Additional Information
IntroductionPro-opiomelanocortin preproprotein (POMC) is a polypeptide hormone precursor which experiences extensive, tissue-specific, post-translational processing via cleavage by subtilisin-like enzymes known as prohormone convertases. POMC regulates the corticosteroid production in the adrenal cortex. Furthermore, POMC is cleaved into ten hormone chains named NPP, g-MSH, ACTH, a-MSH, CLIP, Lipotropin b, Lipotropin g, b-MSH,b endorphin and Met-enkephalin. POMC gene defects are the cause of POMC deficiency, which is characterized by red hair and adrenal insufficiency.
SynonymsPro-opiomelanocortin, POMC, Corticotropin-lipotropin, LPH, MSH, NPP, POC, ACTH, CLIP.
SourceEscherichia Coli.
Physical AppearanceSterile Filtered colorless solution.
FormulationPOMC protein solution (0.25mg/ml) containing 20mM Tris-HCl buffer (pH 8.0), 1mM DTT, 50% glycerol and 0.2M NaCl.
StabilityStore at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Amino Acid SequenceMGSSHHHHHH
SSGLVPRGSH
MWCLESSQCQ
DLTTESNLLE
CIRACKPDLS
AETPMFPGNG
DEQPLTENPR
KYVMGHFRWD
RFGRRNSSSS
GSSGAGQKRE
DVSAGEDCGP
LPEGGPEPRS
DGAKPGPREG
KRSYSMEHFR
WGKPVGKKRR
PVKVYPNGAE
DESAEAFPLE
FKRELTGQRL
REGDGPDGPA
DDGAGAQADL
EHSLLVAAEK
KDEGPYRMEH
FRWGSPPKDK
RY
PurityGreater than 85.0% as determined by SDS-PAGE.
UsageNeoScientific's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drµgs, agricultural or pesticidal products, food additives or household chemicals.
Background

N/A

Protocol

N/A

MSDS
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