Prelamin-A-Other

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Prelamin-A

Qty


Total
$65
Catalog #
PRPS-696
Size
Description
Recombinant Prelamin-A is a 74kDa precursor of the nuclear lamin A protein. Prelamin-A is a structural component of the nuclear lamina and it is encoded by lamin A/C gene (LMNA). Due to the presence of a CAAX box sequence at carboxyl terminus, Prelamin-A in vivo goes throµgh a serial of post-translational modifications, resulting in the farnesylation of the cysteine thiol, removal of the AAX tripeptide, carboxyl-methylation of the cysteinyl carboxy group and proteolysis of 18 C-terminal amino acids residues that lead to mature lamin A. Diverse mutations in the lamin A/C gene are associated with different deseases that are collectively called laminophaties, including Emery-Dreifuss muscular dystrophy, familial partial lipodystrophy, limb girdle muscular dystrophy, dilated cardiomyopathy, Charcot-Marie-Tooth disease, and Hutchinson-Gilford progeria syndrome.
Additional Information
IntroductionNULL
SynonymsNULL
SourceEscherichia Coli.
Physical AppearanceSterile filtered colorless solution.
FormulationThe Prelamin-A solution (0.1mg/ml) contains 10% Glycerol.
StabilityStore at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Amino Acid SequenceMSKGEELFTG
VVPILVELDG
DVNGHKFSVS
GEGEGDATYG
KLTLKFICTT
GKLPVPWPTL
VTTFSYGVQC
FSRYPDHMKQ
HDFFKSAMPEGYVQERTIFF
KDDGNYKTRA
EVKFEGDTLV
NRIELKGIDF
KEDGNILGHK
LEYNYNSHNV
YIMADKQKNG
IKVNFKIRHN
IEDGSVQLADHYQQNTPIGD
GPVLLPDNHY
LSTQSALSKD
PNEKRDHMVL
LEFVTAAGIT
HGMD
PurityGreater than 90% as determined by SDS-PAGE.
UsageNeoScientific's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drµgs, agricultural or pesticidal products, food additives or household chemicals.
Background

N/A

Protocol

N/A

MSDS
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