PRNP Human-Other

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PRNP Human

Qty


Total
$65
Catalog #
PRPS-1407
Size
Description
PRNP Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 229 amino acids (23-230a.a) and having a molecular mass of 25kDa. GOSR2 is fused to a 21 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
Additional Information
IntroductionPrion protein (PRNP) is a ubiquitous membrane glycoprotein whose abnormal self-replicating, misfolded form is widely believed to cause several central nervous system disorders, together known as Transmissible Spongiform Encephalopathies (TSE). PRNP contains a highly unstable region of five tandem octapeptide repeat. Mutations in PRNP protein’s repeat region as well as elsewhere have been associated with Creutzfeldt-Jakob disease, fatal familial insomnia, Gerstmann-Straussler disease, Huntington disease-like 1, and kuru.
SynonymsASCR, CD230, CJD, GSS, MGC26679, prion, PRIP, PrP, PrP27-30, PrP33-35C, PrPc, Major prion protein, PRNP.
SourceE.coli.
Physical AppearanceSterile Filtered colorless solution.
FormulationPRNP protein solution (0.25mg/ml) containing 20mM Tris-HCl buffer (pH 8.0), 1M Urea and 10% glycerol.
StabilityStore at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Amino Acid SequenceMGSSHHHHHH
SSGLVPRGSH
MKKRPKPGGW
NTGGSRYPGQ
GSPGGNRYPP
QGGGGWGQPH
GGGWGQPHGG
GWGQPHGGGW
GQPHGGGWGQ
GGGTHSQWNK
PSKPKTNMKH
MAGAAAAGAV
VGGLGGYVLG
SAMSRPIIHF
GSDYEDRYYR
ENMHRYPNQV
YYRPMDEYSN
QNNFVHDCVN
ITIKQHTVTT
TTKGENFTET
DVKMMERVVE
QMCITQYERE
SQAYYQRGS.
PurityGreater than 90% as determined by SDS-PAGE.
UsageNeoScientific's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drµgs, agricultural or pesticidal products, food additives or household chemicals.
Background

N/A

Protocol

N/A

MSDS
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