PTGDS Human-Other

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PTGDS Human

Qty


Total
$65
Catalog #
PRPS-323
Size
Description
The Human PTGDS His-Tagged Recombinant Protein, produced in E. coli, is 20.3 kDa protein containing 168 amino acid residues of the human PTGDS and 14 additional amino acid residues - HisTag (underlined).
Additional Information
IntroductionBeta-Trace catalyzes the conversion of PGH2 to PGD2, a prostaglandin involved in smooth muscle contraction/relaxation and a potent inhibitor of platelet aggregation. Involved in a variety of CNS functions, such as sedation, NREM sleep and PGE2-induced allodynia, and may have an anti-apoptotic role in oligodendrocytes. Binds small non-substrate lipophilic molecules, including biliverdin, bilirubin, retinal, retinoic acid and thyroid hormone, and may act as a scavenger for harmful hydrophopic molecules and as a secretory retinoid and thyroid hormone transporter. Possibly involved in development and maintenance of the blood-brain, blood-retina, blood-aqueous humor and blood-testis barrier. It is likely to play important roles in both maturation and maintenance of the central nervous system and male reproductive system.It has been proposed that the urinary and serum levels may provide a sensitive indicator of renal damage in diabetes mellitus and hypertension. Elevated levels in the coronary circulation may also be associated with angina. Changes in charge and molecular weight microheterogeneity, due to modification of the N-linked oligosaccharides, may be associated with neurodegenerative disease and multiple sclerosis. Detected in meningioma but not in other brain tumors and may be considered a specific cell marker for meningioma.
SynonymsProstaglandin-H2 D-isomerase, EC 5.3.99.2, Lipocalin-type prostaglandin-D synthase, Glutathione-independent PGD synthetase, Prostaglandin-D2 synthase, PGD2 synthase, PGDS2, PGDS, Beta-trace protein, Cerebrin-28, PTGDS, PDS, BTP, Beta Trace.
SourceEscherichia Coli.
Physical AppearanceSterile Filtered White lyophilized (freeze-dried) powder.
FormulationFiltered (0.4 micron) and lyophilized from 0.5 mg/ml in 20mM Tris buffer, 20mM NaCl, pH 7.5.
SolubilityIt is recommended to reconstitute the lyophilized PTGDS in sterile 18MΩ-cm H2O not less than 100µg/ml, which can then be further diluted to other aqueous solutions.
StabilityLyophilized PTGDS althoµgh stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution PTGDS should be stored at 4°C between 2-7 days and for future use below -18°C.For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please prevent freeze-thaw cycles.
Amino Acid SequenceMRGSHHHHHH
GMASAPEAQV
SVQPNFQQDK
FLGRWFSAGL
ASNSSWLREK
KAALSMCKSV
VAPATDGGLN
LTSTFLRKNQ
CETRTMLLQP
AGSLGSYSYR
SPHWGSTYSV
SVVETDYDQY
ALLYSQGSKG
PGEDFRMATL
YSRTQTPRAE
LKEKFTAFCK
AQGFTEDTIV
FLPQTDKCMT
EQ.
PurityGreater than 95.0% as determined by:(a) Analysis by RP-HPLC.(b) Analysis by SDS-PAGE.
UsageNeoScientific's products are furnished for LABORATORY RESEARCH USE ONLY. They may not be used as drµgs, agricultural or pesticidal products, food additives or household chemicals.
Background

N/A

Protocol

N/A

MSDS
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