PTX3 Human-Other

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PTX3 Human

Qty


Total
$65
Catalog #
PRPS-701
Size
Description
Recombinant Human PTX3 produced in E.Coli is a single, non-glycosylated polypeptide chain containing 401 amino acids (18-381 a.a) and having a molecular mass of 44.4 kDa. PTX3 is fused to a 36 amino acid His Tag at N-terminus and purified by proprietary chromatographic techniques.
Additional Information
IntroductionPTX3 is part of the pentraxin family sharing the C-terminal domain with short pentraxins and containing a unique N-terminal domain. PTX3 is produced and released at inflammatory sites by various cell types including monocytes/macrophages, endothelial cells, vascular smooth muscle cells, fibroblasts, and adipocytes. PTX3 is involved in the regulation of innate resistance to pathogens, inflammatory reactions, possibly clearance of self-components and female fertility. PTX3 is used as a marker for disease activity of psoriasis. High serum PTX3 levels are associated with the disease severity of systemic sclerosis. Elevated serum PTX3 is associated with pulmonary fungal infections.
SynonymsTSG-14, TNFAIP5, PTX3, Pentraxin-related protein PTX3, Pentaxin-related protein PTX3, Tumor necrosis factor-inducible gene 14 protein, TSG14, pentraxin-related gene rapidly induced by IL-1 beta.
SourceEscherichia Coli.
Physical AppearanceSterile filtered colorless solution.
FormulationThe PTX3 protein contains 20mM Tris-HCl buffer pH-8.5, 1mM DTT and 10% glycerol.
StabilityStore at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Avoid multiple freeze-thaw cycles.
Amino Acid SequenceMRGSHHHHHH
GMASMTGGQQ
MGRDLYDDDD
KDRWGSMENS
DDYDLMYVNL
DNEIDNGLHP
TEDPTPCDCG
QEHSEWDKLF
IMLENSQMRE
RMLLQATDDV
LRGELQRLRE
ELGRLAESLA
RPCAPGAPAE
ARLTSALDEL
LQATRDAGRR
LARMEGAEAQ
RPEEAGRALA
AVLEELRQTR
ADLHAVQGWA
ARSWLPAGCE
TAILFPMRSK
KIFGSVHPVR
PMRLESFSAC
IW
PurityGreater than 90% as determined by Analysis by SDS-PAGE.
UsageNeoScientific's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drµgs, agricultural or pesticidal products, food additives or household chemicals.
Background

N/A

Protocol

N/A

MSDS
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