RAN Human-Member RAS Oncogene Family

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RAN Human

Qty


Total
$65
Catalog #
PRPS-848
Size
Description
RAN Recombinant Human produced in E.Coli is a single, non-glycosylated polypeptide chain containing 236 amino acids (1-216 a.a.) and having a molecular mass of 26.5 kDa. The RAN is fused to a 20 amino acid His-Tag at N-terminus and purified by proprietary chromatographic techniques.
Additional Information
IntroductionRAN is a GTP-binding protein that participates in nucleocytoplasmic transport. RAN is necessary for the import of protein into the nucleus and also for RNA export. RAN takes part in chromatin condensation and control of cell cycle. The RAN complex with BIRC5 participates in mitotic spindle formation by being as a physical scaffold to assist the delivery of the RAN effector molecule TPX2 to microtubules. RUN increases AR-mediated transactivation.
SynonymsARA24, Gsp1, TC4, GTP-binding nuclear protein Ran, GTPase Ran, Ras-related nuclear protein, Ras-like protein TC4, Androgen receptor-associated protein 24, Ras-like, RANP1.
SourceEscherichia Coli.
Physical AppearanceSterile filtered colorless solution.
FormulationRAN Human solution containing 20mM Tris-HCl pH-8,1mM DTT & 10% glycerol.
StabilityStore at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Amino Acid SequenceMGSSHHHHHH
SSGLVPRGSH
MAAQGEPQVQ
FKLVLVGDGG
TGKTTFVKRH
LTGEFEKKYV
ATLGVEVHPL
VFHTNRGPIK
FNVWDTAGQE
KFGGLRDGYY
IQAQCAIIMF
DVTSRVTYKN
VPNWHRDLVR
VCENIPIVLC
GNKVDIKDRK
VKAKSIVFHR
KKNLQYYDIS
AKSNYNFEKP
FLWLARKLIG
DPNLEFVAMP
ALAPPEVVMD
PALAAQYEHD
LEVAQTTALP
DE
PurityGreater than 90.0% as determined by SDS-PAGE.
UsageNeoScientific's products are furnished forLABORATORY RESEARCHUSEONLY. The product may not be used as drµgs, agricultural or pesticidal products, food additives or household chemicals.
Background

N/A

Protocol

N/A

MSDS
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