RARRES2 Human-Other

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RARRES2 Human

Qty


Total
$65
Catalog #
PRPS-795
Size
Description
RARRES2 Human Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 138 amino acids and having a total molecular mass of 16 kDa. RARRES2 Human Recombinant is purified by proprietary chromatographic techniques.
Additional Information
IntroductionRARRES2 is a secreted chemotactic protein that initiates chemotaxis throµgh the ChemR23 G protein-coupled seven-transmembrane domain ligand. RARRES2 is upregulated by the synthetic retinoid tazarotene and found in a vast variety of tissues. RARRES2 acts as an adipokine, and is truncated on both termini from the proprotein.RARRES2 is structurally related to the cathelicidin precursors, cystatin C and kininogens. RARRES2 promotes calcium mobilization and chemotaxis of immature dendritic cells and macrophages. RARRES2 is secreted as a precursor of little biological activity, which requires proteolytic cleavage of its COOH-terminal domain to be exchangeed into a potent and highly specific agonist of ChemR23. RARRES2 signals via its receptor, ChemR23 (CMKLR1), as a positive regulator of adipocyte differentiation and metabolic function. The Chemerin receptor acts as a coreceptor for SIV and some primary HIV-1 strains. The Chemerin receptor has another ligand, called tazarotene-induced gene
SynonymsChemerin, TIG2, Tazarotene-induced gene 2 protein, Retinoic acid receptor responder protein 2, RAR-responsive protein TIG2, RARRES2, HP10433.
SourceEscherichia Coli.
Physical AppearanceSterile Filtered White lyophilized (freeze-dried) powder.
FormulationThe RARRES2 protein was lyophilized from 0.02% TFA.
SolubilityIt is recommended to reconstitute the lyophilized Chemerin in sterile 18MΩ-cm H2O not less than 100µg/ml, which can then be further diluted to other aqueous solutions.
StabilityLyophilized Chemerin althoµgh stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution Chemerin should be storedat 4°C between 2-7 days and for future use below -18°C.For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please prevent freeze-thaw cycles.
Amino Acid SequenceMELTEAQRRG
LQVALEEFHK
HPPVQWAFQE
TSVESAAVDTP
FPAGIFVRLE
FKLQQTSRK
RDWKKPECKV
RPNGRKRKCL
ACIKLGSEDK
VLGRLVHCPI
ETQVLREAEE
HQETQCLRVQ
RAGEDPHSFY
FPGQFAFS.
PurityGreater than 98.0% as determined by: (a) Analysis by RP-HPLC. (b) Analysis by SDS-PAGE.
UsageNeoScientific's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drµgs, agricultural or pesticidal products, food additives or household chemicals.
Background

N/A

Protocol

N/A

MSDS
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