Recoverin Human-Other

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Recoverin Human

Qty


Total
$65
Catalog #
PRPS-448
Size
Description
Recoverin Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 200 amino acids & having a molecular mass of 23kDa.
Additional Information
IntroductionRecoverin is a member of the recoverin family of neuronal calcium sensors. Recoverin is a heterogeneously acylated calcium-binding and intracellular signal transduction 23kDa protein in the photoreceptor cells of retina. Recoverin contains four EF-hands, of which two bind Ca. Ca-induced extrusion of the acyl group from a hydrophobic cleft in the protein drives the translocation of recoverin from solution to the disc membrane. Recoverin may prolong the termination of the phototransduction cascade in the retina by blocking the phosphorylation of photo-activated rhodopsin. Recoverin plays a key role in the inhibition of rhodopsin kinase, a molecule that regulates the phosphorylation of rhodopsin. This in due course controls the ability of the eye to adapt to, and recover from, exposure to the presence of light. Recoverin is a detectable serologic protein that is expressed in patients with cancer-associated retinopathy, a paraneoplastic syndrome.
SynonymsRCV1, Cancer-associated retinopathy protein, Protein CAR, RCVRN, Recoverin.
SourceEscherichia Coli.
Physical AppearanceSterile filtered colorless solution.
FormulationThe protein (1mg/ml) contains 20mM Tris-HCI pH 8.0, 1mM EDTA, 2mM MgCl2 and 10% Glycerol.
StabilityStore at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Avoid multiple freeze-thaw cycles.
Amino Acid SequenceMGNSKSGALS
KEILEELQLN
TKFSEEELCS
WYQSFLKDCP
TGRITQQQFQ
SIYAKFFPDT
DPKAYAQHVF
RSFDSNLDGT
LDFKEYVIAL
HMTTAGKTNQ
KLEWAFSLYD
VDGNGTISKNEVLEIVMAIF
KMITPEDVKL
LPDDENTPEK
RAEKIWKYFG
KNDDDKLTEK
EFIEGTLANK
EILRLIQFEP
QKVKEKMKNA.
PurityGreater than 95.0% as determined by(a) Analysis by RP-HPLC.(b) Analysis by SDS-PAGE.
UsageNeoScientific's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drµgs, agricultural or pesticidal products, food additives or household chemicals.
Background

N/A

Protocol

N/A

MSDS
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