ROBLD3 Human-Other

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ROBLD3 Human

Qty


Total
$65
Catalog #
PRPS-057
Size
Description
ROBLD3 Human Recombinant fused with a 24 amino acid His tag at N-terminus produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 149 amino acids (1-125 a.a.) and having a molecular mass of 16kDa. The ROBLD3 is purified by proprietary chromatographic techniques.
Additional Information
IntroductionROBLD3 is a member of the GAMAD family. ROBLD3 is an adapter protein which enhances the efficiency of the MAP kinase cascade and facilitates the activation of MAPK2. ROBLD3 compels the recruitment of MP1 to late endosomes where they form a very stable heterodimeric complex required for ERK activation on endosomes. In humans, a mutation in the ROBLD3 gene has been associated with a primary immunodeficiency syndrome, and sµggests a role for the ROBLD3 protein in endosomal biogenesis.
SynonymsRagulator complex protein LAMTOR2, Endosomal adaptor protein p14, Late endosomal/lysosomal Mp1-interacting protein, Late endosomal/lysosomal adaptor and MAPK and MTOR activator 2, Mitogen-activated protein-binding protein-interacting protein, Roadblock do
SourceEscherichia Coli.
Physical AppearanceSterile Filtered colorless solution.
FormulationThe ROBLD3 solution (1 mg/ml) contains 20mM Tris-HCl buffer (pH8.0), 0.2M Nacl, 2mM DTT and 10% glycerol.
StabilityROBLD3 should be stored desiccated below -18°C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please prevent freeze-thaw cycles.
Amino Acid SequenceMGSSHHHHHH
SSGLVPRGSH
MGSHMLRPKA
LTQVLSQANT
GGVQSTLLLN
NEGSLLAYSG
YGDTDARVTA
AIASNIWAAY
DRNGNQAFNE
DNLKFILMDC
MEGRVAITRV
ANLLLCMYAK
ETVGFGMLKA
KAQALVQYLE
EPLTQVAAS.
PurityGreater than 95.0% as determined by SDS-PAGE.
UsageNeoScientific's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drµgs, agricultural or pesticidal products, food additives or household chemicals.
Background

N/A

Protocol

N/A

MSDS
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