SIRT6 Human-Sirtuin

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SIRT6 Human

Qty


Total
$65
Catalog #
PRPS-289
Size
Description
SIRT6 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 375 amino acids (1-355 a.a.) and having a molecular mass of 41 kDa. Recombinant SIRT6 is fused to 20 amino acids His-tag at N-terminus and purified by conventional chromatography techniques.
Additional Information
IntroductionSIRT6 is part of the sirtuin family of proteins (Class IV), homologs to the yeast Sir2 protein. SIRT6 is characterized by a sirtuin core domain. Yeast sirtuin proteins are recognized by their ability to regulate epigenetic gene silencing and suppress recombination of rDNA. SIRT6, a chromatin-associated protein is involved in DNA repair. Human Sirtuins function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity.
SynonymsMono-ADP-ribosyltransferase sirtuin-6, SIR2-like protein 6, SIRT6, SIR2L6, Sirtuin-6.
SourceEscherichia Coli.
Physical AppearanceSterile Filtered colorless solution.
FormulationThe SIRT6 protein solution contains 20mM Tris-HCl pH-8 & 10% glycerol.
StabilitySIRT6 althoµgh stable 4°C for 4 weeks, should be stored desiccated below -18°C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please prevent freeze-thaw cycles.
Amino Acid SequenceMGSSHHHHHH
SSGLVPRGSH
MSVNYAAGLS
PYADKGKCGL
PEIFDPPEEL
ERKVWELARL
VWQSSSVVFH
TGAGISTASG
IPDFRGPHGV
WTMEERGLAP
KFDTTFESAR
PTQTHMALVQ
LERVGLLRFL
VSQNVDGLHV
RSGFPRDKLA
ELHGNMFVEE
CAKCKTQYVR
DTVVGTMGLK
ATGRLCTVAK
ARGLRACRGE
LRDTILDWED
SLPDRDLALA
DEASRNADLS
IT
PurityGreater than 95.0% as determined by(a) Analysis by RP-HPLC.(b) Analysis by SDS-PAGE.
UsageNeoScientific's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drµgs, agricultural or pesticidal products, food additives or household chemicals.
Background

N/A

Protocol

N/A

MSDS
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