SLC4A4 Human-Other

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SLC4A4 Human

Qty


Total
$65
Catalog #
PRPS-695
Size
Description
SLC4A4 produced in E.Coli is a single, non-glycosylated polypeptide chain containing 460 amino acids (1-424 a.a.) and having a molecular mass of 51.5 kDa.SLC4A4 is fused to 37 amino acid His Tag at N-terminus and purified by proprietary chromatographic techniques.
Additional Information
IntroductionSLC4A4 takes part in the regulation of bicarbonate secretion and absorption and intracellular pH. Mutations in SLC4A4 gene are associated with proximal renal tubular acidosis. SLC4A4 is involved in the regulation of intracellular pH in several cell types. SLC4A4 Isoform 2 is particularly expressed in kidney at the level of proximal tubules.Amino acid subsitution in SLC4A4 results in an increase of chloride transport.NBC1 takes part in proximal renal tubular acidosis and ocular abnormalities.
SynonymsKNBC, NBC1, NBC2, Pnbc, HNBC1, hhNMC, SLC4A5, DKFZp781H1314, SLC4A4, Electrogenic sodium bicarbonate cotransporter 1, Sodium bicarbonate cotransporter, Na(+)/HCO3(-) cotransporter, Solute carrier family 4 member 4, kNBC1, NBC, NBCE1.
SourceEscherichia Coli.
Physical AppearanceSterile filtered colorless solution.
FormulationThe SLC4A4 protein solution contains 20mM Tris-HCl, pH-7.5, 0.5mM DTT, 0.1mM PMSF and 10% glycerol.
StabilityStore at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Amino Acid SequenceMRGSHHHHHH
GMASMTGGQQ
MGRDLYDDDD
KDRWGSMSTE
NVEGKPSNLG
ERGRARSSTF
LRVVQPMFNH
SIFTSAVSPA
AERIRFILGEEDDSPAPPQL
FTELDELLAV
DGQEMEWKET
ARWIKFEEKV
EQGGERWSKP
HVATLSLHSL
FELRTCMEKG
SIMLDREASS
LPQLVEMIVDHQIETGLLKP
ELKDKVTYTL
LRKHRHQTKK
SNLRSLADIG
KTVSSASRMF
TNPD
PurityGreater than 90.0% as determined by SDS-PAGE.
UsageNeoScientific's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drµgs, agricultural or pesticidal products, food additives or household chemicals.
Background

N/A

Protocol

N/A

MSDS
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