SNPH Human-Other

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SNPH Human

Qty


Total
$65
Catalog #
PRPS-552
Size
Description
SNPH Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 444 amino acids (1-424) and having a molecular mass of 48.2 kDa.The SNPH is fused to 20 amino acid His-Tag at N-terminus and purified by standard chromatography techniques.
Additional Information
IntroductionSyntaxin-1, synaptobrevin, and SNAP25 cooperate to form the SNARE complex, which is needed for synaptic vesicle docking and fusion SNPH is a neuron-specific protein originally characterized as a binding partner of syntaxin-1. SNPH participates with SNAP25 for the binding to Syntaxin-1 and prevents the construction of the SNARE core complex, thus manageling free syntaxin-1 availability for the assembly of the SNARE complex and potentially regulating synaptic vesicle exocytosis. Expression Syntaphilin appears to be brain-specific. SNPH is an inhibitor of both SNARE-based fusion and dynamin-mediated endocytosis.
SynonymsKIAA0374, MGC46096, bA314N13.5, SNPH, Syntaphilin.
SourceEscherichia Coli.
Physical AppearanceSterile Filtered colorless solution.
FormulationThe Syntaphilin protein solution contains 20mM Tris-HCl pH-8, 1mM DTT and 10% glycerol.
StabilitySNPH althoµgh stable 4°C for 4 weeks, should be stored desiccated below -18°C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please prevent freeze-thaw cycles.
Amino Acid SequenceMGSSHHHHHH
SSGLVPRGSH
MAMSLPGSRR
TSAGSRRRTS
PPVSVRDAYG
TSSLSSSSNS
GSYKGSDSSP
TPRRSMKYTL
CSDNHGIKPPTPEQYLTPLQ
QKEVCIRHLK
ARLKDTQDRL
QDRDTEIDDL
KTQLSRMQED
WIEEECHRVE
AQLALKEARK
EIKQLKQVID
TVKNNLIDKDKGLQKYFVDI
NIQNKKLETL
LHSMEVAQNG
MAKEDGTGES
AGGSPARSLT
RSST
PurityGreater than 90.0% as determined by SDS-PAGE.
UsageNeoScientific's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drµgs, agricultural or pesticidal products, food additives or household chemicals.
Background

N/A

Protocol

N/A

MSDS
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