THAP1 Human-Other

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THAP1 Human

Qty


Total
$65
Catalog #
PRPS-1096
Size
Description
THAP1 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 237 amino acids (1-213 a.a) and having a molecular mass of 27.5kDa.THAP1 is fused to a 24 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
Additional Information
IntroductionTHAP domain-containing protein 1 (THAP1) is a 213 amino acid protein which is restricted to the nucleoplasm and contains one THAPtype zinc finger, a conserved DNA-binding domain. THAP1 is a DNA-binding transcription regulator which regulates endothelial cell proliferation and G1/S cell-cycle progression. In addition, THAP1 has a pro-apoptopic activity by potentiating both serum-withdrawal and TNF-induced apoptosis. THAP1 protein colocalizes with the apoptosis response protein PAWR/PAR-4 in promyelocytic leukemia (PML) nuclear bodies, and serves as a proapoptotic factor which connects PAWR to PML nuclear bodies.
SynonymsTHAP domain-containing protein 1, THAP1, DYT6.
SourceEscherichia Coli.
Physical AppearanceSterile Filtered colorless solution.
FormulationTHAP1 protein solution (1mg/ml) containing 20mM Tris-HCl buffer (pH 8.0), 2M Urea, 10% glycerol, 1mM DTT and 0.2M NaCl.
StabilityStore at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Amino Acid SequenceMGSSHHHHHH
SSGLVPRGSH
MGSHMVQSCS
AYGCKNRYDK
DKPVSFHKFP
LTRPSLCKEW
EAAVRRKNFK
PTKYSSICSE
HFTPDCFKRE
CNNKLLKENA
VPTIFLCTEP
HDKKEDLLEP
QEQLPPPPLP
PPVSQVDAAI
GLLMPPLQTP
VNLSVFCDHN
YTVEDTMHQR
KRIHQLEQQV
EKLRKKLKTA
QQRCRRQERQ
LEKLKEVVHF
QKEKDDVSER
GYVILPNDYF
EI
PurityGreater than 85.0% as determined by SDS-PAGE.
UsageNeoScientific's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drµgs, agricultural or pesticidal products, food additives or household chemicals.
Background

N/A

Protocol

N/A

MSDS
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