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| Introduction | Thymosin is a hormone secreted from the thymus. Its primary function is to stimulate the production of T cells, which are an important part of the immune system.Thymosin also assists in the development of B cells to plasma cells to produce antibodies.The predominant form of thymosin, thymosin b4, is a member of a highly conserved family of actin monomer-sequestering proteins. b-thymosins are the primary regulators of unpolymerized actin, and are essential for maintaining the small cytoplasmic pool of free G-actin monomers required for rapid filament elongation and allowing for the flux of monomers between the thymosin-bound pool and F-actin. |
| Synonyms | Thymosin beta-4, T beta 4, Fx , TB4X, PTMB4, TMSB4. |
| Source | NULL |
| Physical Appearance | Sterile Filtered White lyophilized (freeze-dried) powder. |
| Formulation | The protein (1 mg/ml) was lyophilized with no additives. |
| Solubility | It is recommended to reconstitute the lyophilized Thymosin beta-4 in sterile 18MΩ-cm H2O not less than 100 µg/ml, which can then be further diluted to other aqueous solutions. |
| Stability | Lyophilized Thymosin b4 althoµgh stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution T beta 4 should be stored at 4°C between 2-7 days and for future use below -18°C.For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please prevent freeze-thaw cycles. |
| Purity | Greater than 98.0% as determined by RP-HPLC. |
| Usage | NeoScientific's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drµgs, agricultural or pesticidal products, food additives or household chemicals. |
| References | Title: Regenerative protein thymosin ? -4 is a novel regulator of purinergic signaling.Publication: Published online before printNovember 24, 2010, doi:10.1096/fj.10-169417March 2011The FASEB Journalvol. 25no. 3907-915.Link: http://www.fasebj.org/content/25/3/907.full.pdf+html |
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