TICAM2 Human-Other

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TICAM2 Human

Qty


Total
$65
Catalog #
PRPS-1043
Size
Description
TICAM2 Human Recombinant produced in E.coli is a single, non-glycosylated polypeptide chain containing 259 amino acids (1-235) and having a molecular mass of 29.4kDa.TICAM2 is fused to a 24 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
Additional Information
IntroductionTICAM2 belongs to the Toll/interleukin-1 receptor (TIR) family, a group of proteins which include the Toll-like receptors (TLRs). TICAM2, a cytoplasmic protein, physically bonds TLR4 and TICAM-1 and functionally transfers LPS-TLR4 signaling to TICAM-1, that sequentially activates IRF-3. TICAM2 takes part in IL1-triggered NF-kappa-B activation, operating upstream of IRAK1, IRAK2, TRAF6, and IKBKB.
SynonymsToll-like receptor adaptor molecule 2, TIRP, TRAM, TICAM-2, Putative NF-kappa-B-activating protein 502, Toll-like receptor adaptor protein 3, TIRAP3, cytoplasmic adaptor, TIR domain-containing adapter molecule 2, toll/interleukin-1 receptor (TIR) domain-c
SourceE.coli.
Physical AppearanceSterile Filtered colorless solution.
FormulationThe TICAM2 solution (1mg/ml) contains 20mM Tris-HCl buffer (pH 8.0), 100mM NaCl, 1mM DTT and 10% glycerol.
StabilityStore at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Amino Acid SequenceMGSSHHHHHH
SSGLVPRGSH
MGSHMGIGKS
KINSCPLSLS
WGKRHSVDTS
PGYHESDSKK
SEDLSLCNVA
EHSNTTEGPT
GKQEGAQSVE
EMFEEEAEEE
VFLKFVILHA
EDDTDEALRV
QNLLQDDFGI
KPGIIFAEMP
CGRQHLQNLD
DAVNGSAWTI
LLLTENFLRD
TWCNFQFYTS
LMNSVNRQHK
YNSVIPMRPL
NNPLPRERTP
FALQTINALE
EESRGFPTQV
ER
PurityGreater than 85% as determined by SDS-PAGE.
UsageNeoScientific's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drµgs, agricultural or pesticidal products, food additives or household chemicals.
Background

N/A

Protocol

N/A

MSDS
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