TNIP1 Human-Other

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TNIP1 Human

Qty


Total
$65
Catalog #
PRPS-012
Size
Description
TNIP1 Human Recombinant fused with a 20 amino acid His tag at N-terminus produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 458 amino acids (94-530 a.a.) and having a molecular mass of 51.8kDa. The TNIP1 is purified by proprietary chromatographic techniques.
Additional Information
IntroductionTNFAIP3-interacting protein 1 (TNIP1) interacts with zinc finger protein A20/TNFAIP3 and inhibits TNF-induced NF-kappa-B-dependent gene expression by interfering with a RIP- or TRAF2-mediated transactivation signal. Furthermore, TNIP1 interacts with HIV-1 matrix protein and is packaged into virions and its overexpression can inhibit viral replication. TNIP1 can regulate matrix nuclear localization, both nuclear import of Preintegration complex (PIC) and export of GAG polyprotein and viral genomic RNA during virion production.
SynonymsTNFAIP3-interacting protein 1, HIV-1 Nef-interacting protein, Nef-associated factor 1, Naf1, Nip40-1, Virion-associated nuclear shuttling protein, VAN, hVAN, TNIP1, KIAA0113, NAF1, ABIN-1.
SourceEscherichia Coli.
Physical AppearanceSterile Filtered colorless solution.
FormulationThe TNIP1 solution (0.25 mg/ml) contains 20mM Tris-HCl buffer (pH7.5), 20% glycerol, 5mM DTT and 200mM NaCl.
StabilityTNIP1 should be stored desiccated below -18°C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please prevent freeze-thaw cycles.
Amino Acid SequenceMGSSHHHHHH
SSGLVPRGSH
MSNVTASPTA
PACPSDKPAP
VQKPPSSGTS
SEFEVVTPEE
QNSPESSSHA
NAMALGPLPR
EDGNLMLHLQ
RLETTLSVCA
EEPDHGQLFT
HLGRMALEFN
RLASKVHKNE
QRTSILQTLC
EQLRKENEAL
KAKLDKGLEQ
RDQAAERLRE
ENLELKKLLM
SNGNKEGASG
RPGSPKMEGT
GKKAVAGQQQ
ASVTAGKVPE
VVALGAAEKK
VK
PurityGreater than 75.0% as determined by SDS-PAGE.
UsageNeoScientific's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drµgs, agricultural or pesticidal products, food additives or household chemicals.
Background

N/A

Protocol

N/A

MSDS
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