TOLLIP Human-Other

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TOLLIP Human

Qty


Total
$65
Catalog #
PRPS-235
Size
Description
TOLLIP produced in E.Coli is a single, non-glycosylated polypeptide chain containing 294 amino acids (1-274 a.a) and having a molecular mass of 32.4kDa.TOLLIP is fused to a 20 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
Additional Information
IntroductionToll interacting protein (TOLLIP) is an inhibitory adaptor protein within Toll-like receptors. The TLR pathway is a part of the innate immune system which recognizes structurally conserved molecular patterns of microbial pathogens, initiating an inflammatory immune response. Negative regulation of TLR signaling by TOLLIP might restrict the production of proinflammatory mediators during inflammation and infection. Furthermore, TOLLIP forms a complex with Tom1 to regulate endosomal transferring of ubiquitinated proteins.
SynonymsToll-interacting protein, TOLLIP, IL-1RAcPIP.
SourceEscherichia Coli.
Physical AppearanceSterile Filtered colorless solution.
FormulationTOLLIP protein solution (0.25mg/ml) containing 20mM Tris-HCl buffer (pH8.0), 40% glycerol, 0.2M NaCl and 2mM DTT.
StabilityTOLLIP Human Recombinant althoµgh stable at 4°C for 1 week, should be stored below -18°C. Please prevent freeze thaw cycles.
Amino Acid SequenceMGSSHHHHHH
SSGLVPRGSH
MATTVSTQRG
PVYIGELPQD
FLRITPTQQQ
RQVQLDAQAA
QQLQYGGAVG
TVGRLNITVV
QAKLAKNYGM
TRMDPYCRLR
LGYAVYETPT
AHNGAKNPRW
NKVIHCTVPP
GVDSFYLEIF
DERAFSMDDR
IAWTHITIPE
SLRQGKVEDK
WYSLSGRQGD
DKEGMINLVM
SYALLPAAMV
MPPQPVVLMP
TVYQQGVGYV
PITGMPAVCS
PG
PurityGreater than 85.0% as determined by SDS-PAGE.
UsageNeoScientific's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drµgs, agricultural or pesticidal products, food additives or household chemicals.
Background

N/A

Protocol

N/A

MSDS
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