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+1-888.733.6849
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+1-888.733.6849
+1-617.299.7367 (Int’l)
| Introduction | TRIM21 is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The 52 kDa Ro protein is part of the RoSSA ribonucleoprotein, which includes a single polypeptide and one of four small RNA molecules. The RoSSA particle localizes to both the cytoplasm and the nucleus. Ro/SSA interacts with autoantigens in patients with Sjogren syndrome and systemic lupus erythematosus. Ribonucleoprotein particle is composed of a single polypeptide and one of four small RNA molecules. The RoSSA is present in all mammalian cells studied but has no known function. At least 2 isoforms are present in nucleated and red blood cells, and tissue specific differences in Ro/SSA proteins were identified. |
| Synonyms | 52 kDa Ro protein, Sjoegren syndrome type A antigen, SS-A, Ro(SS-A), 52 kDa ribonucleoprotein autoantigen Ro/SS-A, Tripartite motif-containing protein 21, RING finger protein 81, TRIM21, RNF81, RO52, SSA1, SSA, RO-52. |
| Source | Sf9 insect cells. |
| Physical Appearance | Sterile Filtered clear solution. |
| Formulation | TRIM21 is supplied in 20mM HEPES pH-7.5, 0.01mM EDTA and 0.02% SDS. |
| Purity | Greater than 90% as determined by SDS-PAGE. |
| Usage | NeoScientific's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drµgs, agricultural or pesticidal products, food additives or household chemicals. |
| References | 1. Title:graft-versus-host disease Recovery of B-cell homeostasis after rituximab in chronic.Publication:doi:10.1182/blood-2010-10-307819 Prepublished online November 19, 2010;2011 117: 2275-2283.Link:http://bloodjournal.hematologylibrary.org/content/117/7/2275.full.pdf+html |
| Applications | Western blot with:a) SLE sera (secondary Sjogren’s syndrome).b) Monoclonal anti-hexa-His-tag antibody. |
| Storage | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. Avoid multiple freeze-thaw cycles. |
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