VEGFB Human-VEGF

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VEGFB Human

Qty


Total
$65
Catalog #
CYPS-635
Size
Description
VEGFB Human Recombinant produced in E.Coli is a double, non-glycosylated, polypeptide chain containing 207 amino acids (22-207) and having a molecular mass of 21.6 kDa.The VEGFB is fused to a 20 amino acid His Tag at N-terminus & purified by proprietary chromatographic techniques.
Additional Information
IntroductionVEGFB is a growth factor for endothelial cells. VEGFB 167 a.a. binds heparin and neuropilin-1 while the binding to neuropilin-1 of VEGFB 186 a.a. is regulated by proteolysis. Overexpression of VEGFB in mouse heart alters cardiac lipid metabolism and induces myocardial hypertrophy. Increased VEGFB expression is associated with hepatocellular carcinoma. VEGF-B has restricted angiogenic activity in the ischemic heart. VEGFB binds to VEGFR1, Flt1, but not to VEGFR2 and VEGFR3. VEGFB is homodimeric, heparin-binding glycoprotein involved in embryonic angiogenesis and vasculogenesis.
SynonymsVascular endothelial growth factor B, VEGF-B, VRF, VEGFL, VEGF-related factor, VEGFB.
SourceEscherichia Coli.
Physical AppearanceSterile Filtered colorless liquid formulation.
FormulationThe VEGFB protein solution contains 20mM Tris-HCl buffer pH 7.5 & 10% glycerol.
StabilityStore at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Amino Acid SequenceMGSSHHHHHH
SSGLVPRGSH
MPVSQPDAPG
HQRKVVSWID
VYTRATCQPR
EVVVPLTVEL
MGTVAKQLVP
SCVTVQRCGG
CCPDDGLECV
PTGQHQVRMQ
ILMIRYPSSQ
LGEMSLEEHS
QCECRPKKKD
SAVKPDRAAT
PHHRPQPRSV
PGWDSAPGAP
SPADITHPTP
APGPSAHAAP
STTSALTPGP
AAAAADAAAS
SVAKGGA.
PurityGreater than 90.0% as determined by SDS-PAGE.
Biological ActivityMeasured in a cell proliferation assay using NIH-3T3 mouse embryonic fibroblast. The ED50 for this effect is < 1ng/ml corresponding to a specific activity of less than 1,000,000units/mg.
UsageNeoScientific's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drµgs, agricultural or pesticidal products, food additives or household chemicals.
Background

N/A

Protocol

N/A

MSDS
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