VEGFR2 Human-VEGF Receptors

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VEGFR2 Human

Qty


Total
$65
Catalog #
PKPS-249
Size
Description
Soluble VEGFR-2 Human Recombinant produced in baculovirus is monomeric, glycosylated, polypeptide having a molecular mass of 116 kDa. The soluble receptor protein contains only the first 7 extracellular domains, which contain all the information necessary for ligand binding.The sKDR is purified by proprietary chromatographic techniques.
Additional Information
IntroductionEndothelial cells express three different vascular endothelial growth factor (VEGF) receptors, belonging to the family of receptor tyrosine kinases (RTKs). They are named VEGFR-1 (Flt-1), VEGFR-2 (KDR/Flk-1), VEGFR-3 (Flt-4). Their expression is almost exclusively restricted to endothelial cells, but VEGFR-1 can also be found on monocytes. All VEGF-receptors have seven immunoglobulin-like extracellular domains, a single transmembrane region and an intracellular split tyrosine kinase domain. VEGFR-2 has a lower affinity for VEGF than the Flt-1 receptor, but a higher signaling activity. Mitogenic activity in endothelial cells is mainly mediated by VEGFR-2 leading to their proliferation.Differential splicing of the flt-1 gene leads to the formation of a secreted, soluble variant of VEGFR-1 (sVEGFR-1). No naturally occuring, secreted forms of VEGFR-2 have so far been reported. The binding of VEGF165 to VEGFR-2 is dependent on heparin.
SynonymsKDR D1-7, sKDR D1-7, Kinase insert domain receptor, Protein-tyrosine kinase receptor Flk-1, CD309, type III receptor tyrosine kinase, FLK1, VEGFR-2.
SourceInsect Cells.
Physical AppearanceSterile Filtered White lyophilized (freeze-dried) powder.
FormulationKDR was lyophilized from a concentrated (1 mg/ml) sterile solution containing 25mM MES pH-5.5 and 100mM NaCl.
SolubilityIt is recommended to reconstitute the lyophilized VEGFR2 in sterile water not less than 100
StabilityLyophilized VEGFR-2 althoµgh stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution FLK1 should be stored at 4°C between 2-7 days and for future use below -18°C.For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please prevent freeze-thaw cycles.
Amino Acid SequenceASVGLPSVSLD
LPRLSIQKDI
LTIKANTTLQ
ITCRGQRDLD
WLWPNNQSGS
EQRVEVTECS
DGLFCKTLTI
PKVIGNDTGA
YKCFYRETDL
ASVIYVYVQD
YRSPFIASVS
DQHGVVYITE
NKNKTVVIPC
LGSISNLNVS
LCARYPEKRF
VPDGNRISWD
SKKGFTIPSY
MISYAGMVFC
EAKINDESYQ
SIMYIVVVVG
YRIYDVVLSP
SHGIELSVGE
KLVLNCTART
E
PurityGreater than 95.0% as determined by SDS-PAGE.
UsageNeoScientific's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drµgs, agricultural or pesticidal products, food additives or household chemicals.
Background

N/A

Protocol

N/A

MSDS
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